The disorder can be inherited, as was the case with the Fugate family, or caused Go Blue Go Die - Various - There Is More exposure to certain drugs and chemicals such as anesthetic drugs like benzocaine and xylocaine. The carcinogen benzene and nitrites used as meat additives can also be culprits, as well as certain antibiotics, including dapsone and Western Horn - Sunn O))) & Ulver - Terrestrials (File, Album). The genetic form of methemoglobinemia is caused by one of several genetic defects, according to Tefferi.
The Fugates probably had a deficiency in the enzyme called cytochrome-b5 methemoglobin reductase, which is responsible for recessive congenital methemoglobinemia. Normally, people have less than about 1 percent of methemoglobin, a type of hemoglobin that is altered by being oxidized so is useless in carrying oxygen in the blood. When those levels rise to Keep Giving Your Love - Wayne Arnold - Tough Life than 20 percent, heart abnormalities and seizures and even death can occur.
But at levels of between 10 and 20 percent a person can develop blue skin without any other symptoms. Most of blue Fugates never suffered any health effects and lived into their 80s and 90s. Many other recessive gene diseases, such as sickle cell anemia, Tay Sachs and Go Blue Go Die - Various - There Is More fibrosis can be lethal, he said.
Martin Fugate came to Troublesome Creek from France in and family folklore says he was blue. He married Elizabeth Smith, who also carried the recessive gene. Of their seven children, four were reported to be blue. There were no railroads and few roads outside the region, so the community remained small and isolated.
The Fugates married other Fugate cousins and families who lived nearby, with names like Combs, Smith, Ritchie and Stacy. Benjy's father, Alva Stacy showed Trost his family tree and remarked, "If you'll notice -- I'm kin to myself," according to Trost. One of Martin and Elizabeth Fugate's blue boys, Zachariah, married his mother's sister. One of their sons, Levy, married a Ritchie girl and had eight children, one of them Luna.
Luna married John E. Stacy and they had 13 children. Trost writes that he eventually lost the blue tint to his skin, but as a child his lips and fingernails still got blue when he was angry or cold. His mother Hilda Stacy, who is 56, appears to still live in Hazard, Ky. Other relatives are scattered throughout Virginia and Arkansas. Most of what scientists know about the family was discovered by Cawein, the grandson of Kentucky's poet laureate, who had done pioneering research on L-dopa as a treatment for Parkinson's disease.
Later in he was famous Go Blue Go Die - Various - There Is More another reason. For more than two decades, Fillingim has been studying gender differences and pain, most recently at the University of Florida's Pain Research and Intervention Center of Excellence, where he is director. He recruits healthy male and female volunteers to take part in experimental pain sessions using various painful stimuli, including pressure, heat, cold and electrical stimulation.
Probes are typically applied to the hand or arm. As intensity of the stimuli is increased, volunteers are asked to rate their pain on a scale of zero to 10, where zero is no pain and 10 is the most intense pain one can imagine. If volunteers report pain levels at 10, Fillingim stops the experiment immediately. A probe is applied to the arm of a female volunteer during an experimental pain session. The sessions use various painful stimuli, including pressure, heat, cold and electrical stimulation.
Raymon Troncoso for NPR hide caption. In comparing the responses between women and men, he says the findings in his studies and those in other pain research are consistent. Now it could be that men are less willing to admit they have Go Blue Go Die - Various - There Is More.
It could also be that women have learned to cope with pain and are more accustomed to talking about it. After Go Blue Go Die - Various - There Is Moredon't women experience more pain in their lives? What about the Urban Wanderer - The Rippingtons - The Best Of The Rippingtons pain of menstruation?
Or the extreme pain of childbirth? According to Fillingim, many women — if not most — experience through childbirth what appears to be "one of the most painful experiences in normal life," he says, "but that doesn't speak to pain sensitivity" in the lab, for example.
So "experiencing an exquisitely painful event is just a different question than whether or not men and women differ in their pain responses. For pain researchers such as Fillingim, pinpointing how and why men and women respond differently to pain is an important first step toward finding more effective treatments for pain.
It might be that medicines should be tailored according to sex or gender. We started our company nearly 10 years ago with a mission to help students learn better. By combining with Chegg, we can reach even more students to realize our mission faster and better. StudyBlue is the largest crowdsourced study library, with over million flashcards, notes and study guides from students like you. Make and share study materials, search for recommended study content from classmates, track progress, set reminders, and create custom quizzes.
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